Dennis smith worked in the pharmaceutical industry for more than 30 years since gaining his phd from the university of manchester uk he worked at pfizer global r d at sandwich for 24 years with the role of vice president for pharmacokinetics dynamics and metabolism during his career he directly contributed to the discovery and development of eight nces now retired he is still active . Contents vii 761 glucuronyl and sulpho transferases 90 762 methyl transferases 92 763 glutathione s transferases 93 77 stability to conjugation processes 93 78 pharmacodynamics and conjugation 95 references 97 8 toxicity 99 81 toxicity findings 99 811 pharmacophore induced toxicity 99 812 structure related toxicity 101 813 metabolism induced toxicity 102 82 epoxides 103. 28 development of the unbound free drug model 24 29 unbound drug and drug action 25 210 unbound drug model and barriers to equilibrium 27 211 slow offset compounds 29 212 factors governing unbound drug concentration 31 references 34 pharmacokinetics and metabolism in drug design edited by dasmith h van de waterbeemd dkwalker r . Pharmacokinetics and metabolism in drug design methods and principles in medicinal chemistry volume 31 second revised edition by dennis a smith han van de waterbeemd and don k walker wiley vch weinheim germany 2006 xix 187 pp 175 x 245 cm isbn 3527313680 12500 james t dalton. Dennis a smith han van de waterbeemd and don k walker pharmacokinetics and metabolism in drug design second revised edition 3527608281jpg
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